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Aklanonic acid

VB Rajgarhia, WR Strohl. Minimal Streptomyces strain C5 daunorubicin polyketide biosynthetic genes required for aklanonic acid biosynthesis. J Bacteriol 179 2690-2696, 1997. [Pg.466]

Scheme 3 Common biosynthetic steps from aklanonic acid and nogalonic acid to aklavi-none and nogalavinone, respectively... Scheme 3 Common biosynthetic steps from aklanonic acid and nogalonic acid to aklavi-none and nogalavinone, respectively...
C. Anthracycline Polyketide Synthases Biosynthesis of Aklanonic Acid... [Pg.615]

Aklanonic acid is synthesized via the condensation of nine Cj units derived from mal-onyl-SCoA on a propionyl starter moiety (124,126,236,247,299,304,310). Malonyl-SCoA, the primary precursor of anthracyclinone biosynthesis, is synthesized in Sfrepto-myces sp. strain C5 by acetyl-SCoA carboxylase (318), as expected from the results of K3-labeling experiments (232-234). [Pg.615]

Based on the currently available information, Figure 11 shows the hypothetical biosynthesis of aklanonic acid from propionyl-SCoA and malonyl-SCoA. This pathway is modified from the model proposed by Strohl and Connors (247). based on data obtained by Bartel et al. (245) and Rajgarhia and Strohl (310), using as models both tetracenomycin F2 biosynthesis by minimal tetracenomycin PKS genes (126,252-255.324) and aloesaponarin II biosynthesis by actinorhodin biosynthesis genes (245,321). [Pg.620]

More recently, Dickens et al. (237,280) and Madduri and Hutchittson (238) showed the genes required for conversion of aklanonic acid to aklaviketone (a) dauCfdnrC encodes aklanonic acidtS-adenosyl-L-methiomnc methyltran erase, a homodimeric protein (222) of ca. 45,000 (deduced subunit M, of DauC is 24,319 (237)). These methyl-... [Pg.622]

Piopioiiyl SCoA 9 mak>n -SCoA Aklanonic acid dpsABEFG, douG 6... [Pg.635]

Connors NC, Bartel PL, Strohl WR. Biosynthesis of anthracyclines Enzymic conversion of aklanonic acid to akiavinone and E-thodomycinone by anthracycline-producing strepto-mycetes, J Gen Microbiol 1990 136 1887-1894. [Pg.651]

Wagner C, Eckardc K, Schumann G, Ihn W Tresseh D. Microbial transformation of aklanonic acid, a potential early intermediate in the biosynthesis of anthracyclines. J Antibioc 1984 37 691-692. [Pg.656]

Schumann G, Stengel C, Eckardt K, Ihn W. Biotransfoimatian of aklanonic acid by blocked mutants of anthracycline-producing strains of Sireptomyces gdilaeus and Screptomyces peucetiHS. J Basic Microbiol 1986 26 249-255. [Pg.656]

See other pages where Aklanonic acid is mentioned: [Pg.93]    [Pg.78]    [Pg.79]    [Pg.149]    [Pg.240]    [Pg.101]    [Pg.101]    [Pg.102]    [Pg.120]    [Pg.128]    [Pg.582]    [Pg.615]    [Pg.622]    [Pg.622]    [Pg.622]    [Pg.622]    [Pg.623]    [Pg.623]    [Pg.45]   
See also in sourсe #XX -- [ Pg.93 ]

See also in sourсe #XX -- [ Pg.30 ]

See also in sourсe #XX -- [ Pg.114 ]



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