Akinetic rigid syndrome

Nervous system Fentanyl-induced brady-kinesia occurred in a 58-year-old man with advanced Parkinson s disease who was given fentanyl to a total of 300 micrograms over 36 hours for anesthesia and analgesia in conjunction with battery replacement for deep brain stimulation of the subthalamic nucleus the severe akinetic rigid syndrome abated when fentanyl was withdrawn [87 ]. 

Different distribution characteristics were also observed39 for dopamine (5) and its tris(trimethylsilyl) and tetrakis(trimethylsilyl) derivatives 6 and 7, respectively. In contrast to 5, for which the blood-brain barrier is nearly impermeable, the much more lipophilic silyl derivatives 6 and 7 were found to exhibit central effects when given intraperitoneally to rats. At a dosage of 100 mg per kg, they influence positively the rigid akinetic syndrom, which was induced by reserpine. These results may be explained in terms of a pro-drug behavior of 6 and 7. (In this context see also Reference 40.)... 

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