Ajmaline enzymatic biosynthesis

FALKENHAGEN, H., STOCKIGT, J., Enzymatic biosynthesis of vomilenine, a key intermediate of the ajmaline pathway, catalyzed by a novel cytochrome P450-dependent enzyme from plant cell cultures of Rauwoljia serpentina. Z. Naturforsch., 1995, 50C, 45-53. 

Stockigt J. Enzymatic biosynthesis of monoterpenoid indole alkaloids ajmaline, sarpagine and vindoline. Studies Organ. Chem. 1986 26 497-511. 

Scheme 1 Enzymatic biosynthesis of ajmaline in R. serpentina cell suspensions.

SCHMIDT, D., STOCKIGT, J., Enzymatic formation of the sarpagan-bridge A key step in the biosynthesis of sarpagine- and ajmaline-type alkaloids. Planta Med., 1995,61,254-258. 

Figure Simplified scheme for the biosynthesis of the antiar- > rhythmic agent ajmaline. Only the key steps are shown in the scheme. The cofactors given on the left side participate in individual enzymatic reactions. The following enzymes were identified in the 15-step sequence leading to the final product ajmaline 1 strictosidine synthase 2 strictosidine glucosidase ...

The enzyme-catalyzed biosynthesis of the sarpagan-ajmalan-type firni-ihes of monoterpenoid indole alkaloids in the genus Rauvolfia, in particular R. serpentina Benth. ex Kurz, have recendy been delineated in detail. The major pathway leading to the structural intricate antiarrhythmic ajmaline, together with several side routes and bypasses, form a comprehensive and complex anabolic network of which a multitude of single-enzymatic... 

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