Aim for Higher Chemoselectivity to Avoid Protecting Groups

Chemoselectivity is still one of the big issues in organic chemistry. Accordingly, the development of functional group-tolerant skeleton-forming reactions will see 

Although such catalysts cannot be found overnight, one sees the direction which synthesis method research is taking these days, and with every new such catalyst developed, the need for using protecting groups will diminish. 

This example demonstrates that exploitation of the innate reactivity [13] of a functional group (combination) may allow for chemoselective transformations and may thus render the use of protecting groups obsolete. 

Change the Order of Synthesis Steps to Avoid Protecting Croups 

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