Agricultural Agents

Veterinary and Agricultural Agents. Thiophencyclopropanecarboxylic a, id49o,49i and derivatives of 3,4-dihydroxythiophen have been patented as pesticides. Compounds such as (219) and (220), and others, have also been suggested as pesticides. 

Miscellaneous Activities. Great interest in the synthesis of biotin and intermediates for biotin can be noted Other biological aspects of 

Madulo-Leblond, P. Gayial, J. Guillaumel, J.-M. Qavel, P. Demerseman, and R. Royer, Eur. J. Med. Chem. -Chim. Ther., 1981, 16, 267. 

Bayssat, F. Sautel, J. C. Depin, and A. Betbeder-Matibet, USSR P. 795 472, 1981 (Otkrytiya, Izobret, Prom. Obraztsy, Tovamye Znaki, 1981, 229). 

Staben, A. S. Bhargava, C. Schobel, F. Siegmund, and P. Giinzel, Arzneim.-Forsch., 

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Over the past decade, the use of polymers for the administration of pharmaceutical and agricultural agents has increased dramatically. 

Although environmental nephrotoxicants differ markedly in their chemical nature, there are several distinct classes of environmental nephrotoxicants. These classes include the metals, halogenated solvents, agricultural agents, and natural products. A diverse array of miscellaneous nephrotoxicants also exists and will be discussed briefly at the end of this section. 

Miscellaneous Nephrotoxicants There are numerous additional agents that have been identified as nephrotoxicants, and some of these chemical and physical agents are shown in Table 8. In addition to the compounds listed, there are hundreds of chemicals whose effects on the kidney are either unknown or are poorly characterized, and unquestionably this list will continue to grow with the ongoing development of newer drugs, agricultural agents, and industrial intermediates. 

Enquiries to the New Zealand National Poisons Information Centre concerning pesticide poisoning exposures accounted for 15% of total telephone enquiries for the year ended June 1993 (see Table 27.1). The breakdown of enquiries with respect to type of agricultural agent is shown in Table 27.2 [10]. 

Table 27 J Telephone enquiries concerning agricultural agents (Julj 1992-June 1993)...

Agricultural agents Adults Children Animals Other Unknown Total... 

Veterinary and Agricultural Agents. Thiophensulphonamides are used as larvicides, insecticides, acaricides and miticides in sheep and cattle.2 ... 

Topics which arc covered in this overview include the role of the computational chemist in the design of new pharmaceutical and agricultural agents, along with descriptions of current trends in the field. Particular emphasis is placed on minicomputer graphics workstations, 3D stractural databases, and the merging of statistical and molecular modeling techniques to predict activity and mechanism. 

Over the past decade, the use of polymers for the administration of pharmaceutical and agricultural agents has increased dramatically. The controlled release technology has changed from being merely useful in research to having a significant impact in the biomedical industry. 

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