Agonist therapeutic uses

The therapeutic potential of HENECA for the treatment of cardiovascular diseases, and the need for more selective A2a agonists prompted us to synthesize a number of new 2-alkynyl derivatives of NECA bearing hydroxyl, amino, chloro, cyano, and heterocyclic groups or substituted aromatic or heteroaromatic rings in the side chain [27,28]. 

A therapeutic alternative for treatment of anxiety and depression is the use of 5-HT1A agonists. Azapirones comprise the major class of 5-HT1A agonists of which buspirone (Buspar [4]) is the only FDA-approved 5-HT1A selective agonist (relative to the other 13 serotonin receptor subtypes) for anxiety currently on the US market (Scheme 19.1). Buspirone has shown efficacy in randomized controlled trials of GAD for which it was approved [5-7]. Unlike benzodiazepines, buspirone is not addictive... 

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