Agonist and antagonist properties

Newman-Tancredi, A., Cussac, D., Quentric, Y., Touzard, M., Verriele, L., Carpentier, N. and Millan, M.J. (2002) Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. III. Agonist and antagonist properties at serotonin, 5-HT... 

The guinea-pig ileum test has been developed [242, 243] to provide quantitative data upon the agonist and antagonist properties of morphine-like drugs. The agonist activity is measured by the concentration of drug which causes 50 per cent depression of the twitch induced by coaxial stimulation (IDso value) and the antagonist activity by the equilibrium constant (A)g). The latter is obtained... 

Mueller SO, Simon S, Chae K, Metzler M, Korach KS. Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor (alpha) and ER(beta) in human cells. Toxicol ScL 81, 530-531, 2004. 

The recognition that dopamine (DA) Is an important neurotransmitter with receptors in both the central nervous system and in the periphery has resulted in a widespread search for substances that either mimic or block the action of this natural neurotransmitter on Its receptors. This has resulted in the discovery of an enormous number of compounds of diverse structure that have DA receptor agonist and antagonist properties. 

Tamoxifen (Nolvadex /AstraZeneca), a nonsteroidal antiestrogen chemotherapeutic possessing both agonistic and antagonistic properties, is used for the treatment and preven-... 

The guinea pig ileum (GPI) test (inhibition of the contraction of electrically stimulated longitudinal muscle by opioid agonsts, p. 3) is a most useful in vitro procedure for dualists since it may be adapted to assess both their agonist and antagonist properties. The agonist activity is measured by... 

BS has been shown to interact with dopamine receptors in vitro. Pharmacologically both DA agonists and antagonist properties have been demonstrated. There is also evidence that serotonin receptors (type 2) are involved as well as interaction with NE and ACh... 

Perlman, S., Costa-Neto, C.M., Miyakawa, A.A., Schambye, H.T., Hjorth, S.A., et al (1997) Dual agonistic and antagonistic property of nonpeptide angiotensin ATI ligands susceptibility to receptor mutations. Mol. Pharmacol. 51 301-311. 

Jard, S Lombard, C., Seyer, R., Aumelas, A., Manning, M. and Sawyer, W.H. (1987) lodination of vasopressin analogues with agonistic and antagonistic properties effects on biological properties and affinity for vascular and renal vasopressin receptors. Mol. Pharmacol. 32 369-375. 

However, complex and anomalous findings have caused uncertainty about the biochemical and functional thyroid status of dioxin treated animals (4). This could be related to a complex Interplay of the potential thyroid hormone agonists and antagonists properties of these toxic compounds. Further studies are needed to investigate a possible link between TCDD (and related compounds)-medlated effects and some aspects of thyroid hormone endocrinology. 

Drugs have both agonistic and antagonistic properties potent analgesics but less addictive than pure opioids Indications [See Opioids]... 

Agonist and antagonist properties of vlmlnol stereoisomers (XIII, previously known as diviminol) were described.31 This confound has 3 asymmetric centers and 6 stereoisomers. Analgesic activity resided in a... 

---