Aglycons Related to Phenanthrene

Strain, in Organic Chemistry(H. Gilman, ed.), 2nd ed., p. 1427. Wiley, New York, 1943 R. Tschesche, Fortschr. Chem. org. Naturstoffe 1, 1 (1945) H. Heusser, ibid. 7, 87 (1950) L. F. FieserandM. Fieser, Natural Products Related to Phenanthrene, 3rd ed., p. 507. Reinhold, New York, 1949. See series of more than 134 articles by T. Reichstein and co-workers Glycoside und Aglycone in Helv. Chim. Acta (1938 to 1954). 

Acids hydrolyze the linkage between the aglycon and the sugars in the cardiac glycosides, and di- and trisaccharides can be isolated. It is stated that this linkage is not hydrolyzed by the enzymes in the same plant, but instead only the glycosidic bonds between the sugars are split. Many of the 

Lanata-glycoside C, glycoside from Digitalis lanaia 

When administered to persons with impaired heart function, cardiac 

Substance Mean lethal dose (cat assay) (micrograms/ kg.) Mean systolic dose (frog assay) (micro-grams/kg.) 

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