Aging in mammals

Barja G (1998) Mitochondrial free radical production and aging in mammals and birds. Ann N Y Acad Sci 854 224-238... 

Bellamy, D., "Hormonal Effects in Relation to Aging in Mammals, St/m-... 

Contraction index. We have observed that %FS declines with age in wildtype flies (12, 23) as it does in some human cardiac diseases and with gene mutations, suggesting that this index could be a reliable marker of heart performance similar to its use in mammals. Representative values for wildtype hearts are shown in Table 1 and the details are described in (23). 

Although the a-D-mannosidase activity of several different organs in mammals has been found to alter under a variety of conditions (see Section 11,1 p. 402),11,12-14,28,28 the most striking changes are those produced by sex hormones in the epididymis and uterus.26,28 In rats and mice, a-D-mannosidase activity in the epididymis increases with the age of the animal, up to maturity orchidectomy causes a dramatic fall in the enzyme activity of the adult tissue (up to 100-fold), but activity can be partially restored by the administration of testosterone. Ovariectomy results in a 10-fold fall in the activity of a-D-mannosidase in mouse uterus, and this is completely reversed by estrone. 

---