Leukemia aggressive NK cell

Makishima H, Ito T, Asano N, et al. Significance of chemokine receptor expression in aggressive NK cell leukemia. Leukemia 2005 19 1169-1174. 

This pair of granule-associated proteins is also localized to cytotoxic T and NK cells. They are essential for both apoptosis and induced cell death of target cells via induction of perforated cell membranes. However, their expression is assumed to be evidence of an activated state. They mark subcutaneous panniculitis-like T-cell lymphoma, aggressive NK-cell leukemia, and extra-nodal NK/T cell lymphoma, nasal type. 

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