Aggressive meningiomas

Grade II and III aggressive meningiomas occur as both specific subtypes (e.g., chordold, rhabdoid) and as the standard subtypes of meningioma with specific ominous features such as mitotic indices of atypical and malignant meningiomas. 

Atypical meningioma is a neoplasm that is likely to be more aggressive than grade 1 meningiomas and to recur locally. 

Atypical meningiomas tend to be aggressive and to recur locally. Chromosomal abnormalities in addition to standard loss of 22 and increased MIBl LI may forecast greater aggressiveness. > 71... 

A highly aggressive tumor, rhabdoid meningioma contains barely cohesive cells that are filled with abundant whorls of filaments that show immunocytochemical reactivity for vimentin. 472 These filaments push the meningothelial nuclei to the side of the cell. 

Perry A, Scheithauer BW, Stafford SL, et al. Rhabdoid meningioma An aggressive variant. Am J Surg Pathol. 1998 22 1482-1490. 

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