Aggregation closure problem

Fourth, in Section 7.4 we examine the closure problem arising in aggregating systems as well as in random environments and some approximations that have been used to obtain closure. 

Aggregation of blood platelets is the requisite first event for the maintenance of intact circulation in the face of any break in a blood vessel. It is the platelet clump that starts the long and complicated process leading to closure of the broken vessel by an organized blood clot. Though this property of platelets is vital to maintenance of the circulatory system, an excessive tendency to aggregation can also lead to problems. Thus platelet clumps formed in blood vessels in the absence of injury can lead to blockade of blood circulation and subsequent injury. Strokes and some types of myocardial infarcts have thus been associated with platelet clumps. The nonsteroid antiinflammatory... 

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