Ages probes, metal ions as

Finally, we discuss the use of metal ions In probing cellular age changes, whether or not these changes were Induced by metal Ions. 

Aluminum appears to be Involved in Alzheimer s disease and concentrates in the nucleus therefore, we have looked at aluminum binding to DNA, and we find that aluminum forms crosslinks with the DNA strands. Metal ions generally produce deleterious effects in genetic information transfer when present in the wrong kind or concentration. They are, however, essential in genetic information transfer. The concentration of metal ions in various cells changes with age, and we have hypothesized that perhaps these metal ions have an Impact on genetic information transfer processes 

ACS Symposium Series American Chemical Society Washington, DC, 1980. 

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