Aged patients Altered pharmacokinetic profile

Elevated gastric pH Decreased gastrointestinal blood flow Decreased active transport mechanisms [Pg.50]

Decreased total body water Decreased lean body mass Increased body fat Decreased senun albumin Decreased liver blood flow Decreased liver size Possibly decreased enzymatic activity Decreased glomerular filtration rate Decreased renal blood flow Decreased tubular function Diminished chohnergic, alpha-1 adrenergic, and opioid receptors [Pg.50]

Statistical analysis has firmly estabhshed four isolated but interrelated facts about die aged population. [Pg.50]

The aged population may have multiple diseases and may be taking multiple medications. [Pg.50]

The potential of drug—drug interactions and adverse drug reactions is a conspicuous problem among die elderly. [Pg.50]

Big Chemical Encyclopedia