Age-and Time-Distribution of Neoplasms

As indicated above, the latent period preceding the appearance of an induced neoplasm may vary with the nature of the carcinogenic stimulus (initiation, promotion, etc.), type of neoplasm, age at exposure, and other factors. These variables must, therefore, be taken into account in estimating the potential impacts of a carcinogen. 

Lifetime ENptmien, Comp iian ot Abiotute ml Retotfve Rifk Modeh 

Limited Cupmeion Time. Reietive Rkk MoM, CemptrH n of Two A -et-Expoture Group  

In order to determine the effective dose of a given agent to the population at risk, evaluators need to take into account such variables as the duration and intensity of exposure, the age distribution of exposed persons at the time of their exposure, their sex, state of disease or health, and the estimated concentrations of the agent and its metabolic derivatives in various tissues of the body. Also, insofar as possible, the mode of action of the agent should be characterized in order to enable selection of the appropriate dose-incidence model for use in risk estimation. 

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