African Americans population size

Figure 1). PCR amplification of the region spanning this polymorphism followed by agarose gel electrophoresis to distinguish the insertion/deletion alleles based on size was performed to determine the frequency of each allele in various populations. In doing so, the deletion allele was found to occur at a frequency of 31% in Caucasians and 12% in African-Americans (Table 1). 

The alleles containing 4 and 9 copies of the TSER repeat were primarily confined to African populations. TSER 4 accounted for 2-7% of TSER alleles in all African populations except the Sudanese. However, TSER 4 was also found in a British Caucasian subject but not among the American-Caucasian population studied [53]. This suggests that TSER 4 occurs at a low frequency in Caucasian populations. The absence of the TSER 4 allele in the Sudanese population may be a result of the small sample size or due to the fact that this allele occurs at very low frequencies in this population. The latter possibility would make sense as this population is an admixture of Negroid and Caucasoid characteristics at both the morphological and molecular levels [17]. 

Population subsamples of American and African blacks, however, show a significantly different bell-shaped Lp(a) distribution (H6, P5, S40) (Fig. 7). The mean levels are twice those in Caucasians, indicating that the Lp(a) distribution depends upon race (G37). As there is an inverse relation between apo(a) size and plasma concentration, the distribution of different genotypes and allele frequencies is also dependent upon race (C6, Ml3). 

---