AFCAPS/TexCAPS

In the general population for primary prevention of CHD The West of Scotland Coronary Prevention Study (WOSCOPS) (9), Air Force/Texas coronary atherosclerosis Prevention study (AFCAPS/TexCAPS) (10), and the completed but unpublished MEGA study in Japan (A. Nakamura, presented to AHA Scientific Sessions, November 2005). 

Downs JR, Clearfield M, Weis S, et al. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study. JAMA 1998 279 1615-1622. 

In AFCAPS/TexCAPS, a primary prevention trial conducted in 6605 men and women aged 57 to 63 years with average total cholesterol and LDL concentrations (<221 mg/dL and <150 mg/dL, respectively) who were treated with lovastatin 20-40 mg/day for 5.2 years, a 37% reduction p <. 001) was shown in the risk for first acute major coronary event (fatal or nonfatal MI, unstable angina, or sudden cardiac death)." The need for revascularization procedures also was reduced by 33% p <. 001). The implications of this trial are enormous potentially millions of normal people could benefit... 

Scandinavian Simvastatin Survival Study AC AT acyl CoA cholesterol acyltransferase AFCAPS/TexCAPS Air Eorce/Texas Coronary Atherosclerosis... 

Primary prevention trials such as Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS) (i i, 72), West of Scotland Coronary Prevention Study Group (WOSCOPS) (13,14), and the... 

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