Aerothionin biosynthesis

Adamantyl haUdes, reactions of 677 p-(l-Adamantyl)phenols, synthesis of 606, 607 Aerophobin-1, biosynthesis of 1315, 1316 Aeroplysinin-1, synthesis of 1327, 1328 Aerothionin, biosynthesis of 1315, 1316 Ageing, free-radical theory of 140, 141 Agent Orange 12... 

Bromo-Olefins from Verongia Sponges.—Full details have been published on the structural elucidation of the bromo-compounds Aeroplysinin-1, Aerothionin, and Homoaerothionin isolated from Verongia sponges. In addition, a new bromo-compound, designated Aeroplysinin-2, has been isolated from the same source, which has added further sustenance to biosynthesis commentary among this closely related group of compounds. 

Quite surprisingly, the first attempt to demonstrate the conversion of tyrosine into bromotyrosine derivatives was unsuccessful (175). In that experiment, Verongia aerophoba failed to incorporate radioactivity from U- " C -L-tyrosine into aerothionin (68), aeroplysinin-1 (14) and the dienone 1. Inactive aerothionin (68) was also isolated when the sponge was fed with U- C -L-ornithine and CH3- C methionine. However, the sponge utihzed these amino acids for the synthesis of fatty acids. A very slow rate of biosynthesis might account for these results. 

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