Adverse drug reactions systemic toxicity

For recent skin-test converters of all ages, the risk of active TB outweighs the risk for drug toxicity.Pregnant women, alcoholics, and patients with poor diets who are treated with isoniazid should receive pyridoxine (vitamin Bg) 10-50 mg daily to reduce the incidence of central nervous system (CNS) effects or peripheral neuropathies. All patients who receive treatment of LTBl should be monitored monthly for adverse drug reactions and for possible progression to active TB. 

Several types of adverse drug reactions do not easily fit into Cell and Coomb s classification scheme. These include most cutaneous hypersensitivity reactions (such as toxic epidermal necrolysis), immune-allergic hepatitis and hypersensitivity pneumonitis. Another difficulty is that allergic drug reactions can occur via more than one mechanism picryl chloride in mice induces both type 1 and type IV responses. Although other classification schemes have been proposed. Cell and Coomb s system remains the most widely utilized scheme [4-7]. 

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