Screening methods, adverse drug reactions

It is an exdting sdentific challenge to develop predictive methods that capture off-target-related adverse drug reactions reliably with a comparatively small number of compounds and at a reduced number of targets to be screened. The perfect scenario of a full data matrix as a starting point was outlined in the first part of this chapter. 

Given the perceived failure of spontaneous reporting systems and the paucity of ADR reports/ some institutions have instituted more active methods of ADR detection to supplement spontaneous reports. Medication order screening has become a common practice in U.S. hospitals. Manual chart reviews and audits and computer programs are used for retrospective/ concurrent/ and prospective medication utilization evaluation. Certain events often prompt an evaluation of a suspected adverse reaction. These include abrupt discontinuation of a medication/ abrupt dosage reduction/ orders for antidotes and emergency medications/ orders for special tests or serum drug concentration measurements/ and abnormal results from laboratory tests and medical procedures. 

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