Advantages of Molecular Adjuvant-Containing Vaccines

This chapter has highlighted some of the characteristics of traditional and non-traditional adjuvants, the advantages and disadvantages of their use in vaccines, and has introduced the concept of molecular adjuvants as a way to improve immune 

The majority of adjuvants in experimental use today are composed of various bacterial components. Briefly explain the rationale for the use of such bacterial components in adjuvants. 

Briefly describe the two major biological functions of the complement system. 

The complement-derived anaphylatoxin C5a has many prominent immune stimulatory properties and, consequently, is a good candidate for use as a molecular adjuvant. However, its use as such would be severely lunited. Describe the major limitation(s) for the use of natural C5a as a molecular adjuvant. 

Antigen presenting cells (APC) represent an important class of iimnune cells essential for generating an antigen-specific immune response. Briefly describe the basic cellular mechanism by wliich APCs contribute to this antigen-specific iimnune outcome. 

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