Advanced metastatic lymphoma

Several phase II evaluations of elliptinium (5) have been carried out in recent years, with mixed results. Elliptinium is typically given to patients intravenously at a concentration of 100 mg/m in a 5% dextrose solution for 1-2 hr. A clinical study of 5 in the treatment of lymphoma was slightly encouraging in that, of 16 evaluable patients, there were 1 partial response and 7 minor responses (278). However, in the treatment of metastatic soft tissue sarcoma, none of the 19 patients had remission of their tumors (279). An extensive phase II trial of advanced breast cancer patients (74) was very encouraging 19% had objective responses, and in those patients with soft tissue metastases the response rate was 30% (280). These responses lasted from 3 to 12 months, and mild to moderate nausea and mouth dryness were the most frequently encountered side effects. 

This technique has a limited role in local staging of patients with penile tumors. In fact, while CT and magnetic resonance imaging are equally effective to identify pathological nodes, the relationships of the tumor with adjacent structures are better evaluated with magnetic resonance imaging because of higher contrast resolution. In advanced penile cancers TC has a role in identification of distant metastatic deposits. CT is also indicated in patients with lymphoma apparently localized to the penis to check for the presence of other localizations of the disease. 

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