Adulterants, hepatotoxicity

Abuse of veterinary phenylbutazone is known to occur and ulcers and renal insufficiency has been reported in a horse trainer who used the drug." Oral intake of around 17 g of a veterinary formulation for toothache by a racetrack worker resulted in grand mal seizures, coma, hypotension, respiratory and renal failure and hepatotoxicity. The patient recovered after six weeks of supportive intensive care and repeated dialysis." Aplastic anaemia in humans has resulted from the use of veterinary phenylbutazone and from the use of a herbal medication adulterated with phenylbutazone." " ... 

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