Adult rat liver epithelial

Tong C, Brat SV, Williams GM. 1981. Sister-chromatid exchange induction by polycyclic aromatic hydrocarbons in an intact cell system of adult rat-liver epithelial cells. Mutat Res 91 467- 473. 

Evidence has accumulated in support of the hypothesis (78,79) that DDT inhibits metabolic cooperation (84,107) thereby causing a loss of control on cell proliferation. DDT was shown to inhibit cell-to-cell communication between primary cultures of hepatocytes and an established adult rat liver epithelial cell, 6-thioguanlne resistant strain (84). Recently, DDT was compared with a phorbol ester and quercetin in the same system and the phrobol ester and DDT were found to be synergistic Indicating that they may act by different pathways (107). The well established promotor action of DDT appears to be consistent with its capacity to inhibit cell-to-cell communication. 

San, R. H. C. and Williams, G. M., Rat hepatocyte primary cell culture-mediated mutagenesis of adult rat liver epithelial cells by procarcinogens. Proc. Soc. Exp. Biol. Med. 156 534-538 (1977). 

Tong, C., Williams, G.M. 1980. Definition of conditions for the detection of genotoxic chemicals in the adult rat-liver epithelial cell/hypoxanthine-guanine phosphoribosyl... 

TABLE 7. Rat-Hepatocyte-Primary-Cell-Culture-Mediated Mutagenesis of Adult Rat Liver Epithelial Cells by Activation-Dependent Carcinogens"... 

G. M. Williams and J. M. Gunn, Long-term cell culture of adult rat liver epithelial cells, Exp. Cell Res. 89, 139-142 (1974). 

G. M. Williams, C. Tong, and J. J. Berman, Characterization of analog resistance and purine metabolism of adult rat-liver epithelial cell 8-azaguanine-resistant mutants, Mutat. Res. 49, 103-115 (1978). 

C. Tong and G. M. Williams, Induction of purine analog-resistant mutants in adult rat liver epithelial lines by metabolic activation-dependent and -independent carcinogens, Mutat. Res. 55,339-352 (1978). 

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