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Conformational changes adsorption

Van Tassel P R, Guemourl L, Ramsden J J, Tar]us G, VIot P and Talbot J 1998 A model for the Influence of conformational change on protein adsorption kinetics J. Colloid Interfaoe Sc/. 207 317-23... [Pg.2851]

The events that follow the initial adsorption of the taste stimulus to the receptor matrix of the taste-cell membrane are conformational changes in... [Pg.211]

It is important to characterize the material adsorbed at the interface, as well as the conformation of the adsorbed proteins, because it determines the properties of the emulsions and gels. However, little is known about the conformational changes of proteins upon adsorption at oil-water interfaces. The main reason for this is the lack of experi-... [Pg.265]

In 1958 Sarda and Desnuelle [79] discovered the lipase activation at the interfaces. They observed that porcine pancreatic lipase in aqueous solution was activated some 10-fold at hydrophobic interfaces which were created by poorly water-soluble substrates. An artificial interface created in the presence of organic solvent can also increase the activity of the lipase. This interfacial activation was hypothesized to be due to a dehydration of the ester substrate at the interface [80], or enzyme conformational change resulting from the adsorption of the lipase onto a hydrophobic interface [42,81,82]. [Pg.567]

Because membrane filtration is the only currently acceptable method of sterilizing protein pharmaceuticals, the adsorption and inactivation of proteins on membranes is of particular concern during formulation development. Pitt [56] examined nonspecific protein binding of polymeric microporous membranes typically used in sterilization by membrane filtration. Nitrocellulose and nylon membranes had extremely high protein adsorption, followed by polysulfone, cellulose diacetate, and hydrophilic polyvinylidene fluoride membranes. In a subsequent study by Truskey et al. [46], protein conformational changes after filtration were observed by CD spectroscopy, particularly with nylon and polysulfone membrane filters. The conformational changes were related to the tendency of the membrane to adsorb the protein, although the precise mechanism was unclear. [Pg.703]

Pevear DC, Fancher MJ, Felock, et al. Conformational changes in the floor of the human rhinovirus canyon blocks adsorption to Hela cell receptors. J Virol 1989 63 2002-2007. [Pg.309]

AG is always negative, and the decrease in free energy can be due to adsorption effects (change in AH) or entropic interactions (change in AS). AS is always operating when the polymer chain cannot occupy all possible conformations in a pore (confined space) due to the limited size of the pore relative to the size of the macromolecule. In a real... [Pg.390]

Michael KE, Vemekar VN, Keselowsky BG, Meredith JC, Latour RA, Garcia AJ (2003) Adsorption-induced conformational changes in fibronectin due to interactions with well-defined surface chemistries. Langmuir 19 8033-8040... [Pg.197]

Adsorption on a Single-Site Polymer with Conformational Changes Induced by the Binding Process... [Pg.51]

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Adsorption changes

Conformation change

Conformational changes

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