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Adrucil - Fluorouracil

The antimetabolites interfere with various metabolic functions of cells, thereby disrupting normal cell functions. They inactivate enzymes or alter the structure of DNA, changing the DNA s ability to replicate These drag are most effective in the treatment of rapidly dividing neoplastic cells. Examples of the antimetabolites include methotrexate and fluorouracil (Adrucil). [Pg.592]

Fluorouracil Adrucil Carcinoma of colon, rectum, stomach, and pancreas Gl distress (loss of appetite, nausea] blood disorders (anemia, leukopenia, thrombocytopenia] skin disorders (rash, hair loss]... [Pg.572]

Adrucil, Arumel, Efudex, Fluril, Fluracil, Fluoroplex, Timazin, 5 fluorouracil, 5-FU, RO 2-9757, NSC 19893. [Pg.274]

Further studies have validated this hypothesis, in part,4 and ultimately this inventive premise was borne out in clinical practice. As a result, 5-FU (5) was eventually approved for treatment of solid tumors, such as breast, colorectal, and gastric cancers. Marketed as Adrucil when administered intravenously, 5-FU can be used either as monotherapy or combination therapy with various cytotoxic drugs and biochemical modulators, such as leucovorin and methotrexate.5 Because 5-fluorouracil is not orally bioavailable, it must be administered by continuous infusion to optimize its efficacy due to its short half-life in plasma. In addition, 5-FU has poor selectivity toward tumors in vivo, and its distribution into tissues such as bone marrow, the gastrointestinal tract, the liver and skin causes high incidences of toxicity. In addition, in spite of its limited lipid solubility, 5-fluorouracil diffuses readily across the blood-brain barrier into cerebrospinal fluid and brain tissue.1,5... [Pg.59]

SYNS ADRUCIL ARUMEL CARZONAL EFFLUDERM (free base) EFUDEX EFUDIX 5-FLUORACIL (GERMAN) FLUOROBLASTIN FLUOROPLEX O 5-FLUORO-2.4-PYRIMDINEDIONE 5-FLUORO-2,4(lH,3H)-PYRIMIDINEDIONE 5-FLUOROURACIL 5-FLUORPROPYRIMIDINE-2,4-DIONE 5-FLUORURACIL (GERMAN) FLURACIL FLURI FLURIL 5-FU NSC-19893 RO 2-9757 TIMAZIN U-8953 ULUP... [Pg.675]

Trade names Adrucil, Efudex, Fluoroplex, Fluorouracil... [Pg.211]

See other pages where Adrucil - Fluorouracil is mentioned: [Pg.1670]    [Pg.352]    [Pg.1175]    [Pg.1670]    [Pg.1670]    [Pg.1389]    [Pg.1343]    [Pg.1387]    [Pg.1670]    [Pg.352]    [Pg.1175]    [Pg.1670]    [Pg.1670]    [Pg.1389]    [Pg.1343]    [Pg.1387]    [Pg.585]    [Pg.351]    [Pg.168]    [Pg.645]    [Pg.78]    [Pg.78]    [Pg.37]    [Pg.373]    [Pg.398]    [Pg.123]    [Pg.37]    [Pg.298]   


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5-fluorouracil

Adrucil

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