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Adriamycin half-life

Zidovudine is rapidly absorbed from the G1 tract with peak serum concentrations occurring within 30 to 90 minutes. It binds to plasma proteins to the extent of 35 to 40%. Zidovudine is rapidly metabolized in the liver to the inactive 3 -azido-3 -deoxy-5 -0-beta-D-glucopyranuronosylthymi-dine (GAZT), which has an apparent elimination half-life of 1 hour. Zidovudine undergoes glomerular filtration and active tubular secretion. Coadministration of zidovudine with agents such as dapsone, pentamidine, amphotericin B, flucytosine, vincristine, vinblastine, adriamycin, and interferon with potential to cause nephrotoxicity or cytotoxicity to hematopoietic elements, enhance its risk of adverse effects. Probenecid will inhibit the renal excretion of zidovudine. [Pg.743]


See other pages where Adriamycin half-life is mentioned: [Pg.599]    [Pg.215]    [Pg.143]    [Pg.146]    [Pg.156]    [Pg.143]    [Pg.146]    [Pg.156]    [Pg.370]   
See also in sourсe #XX -- [ Pg.370 ]




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