Adrenolytic agents

Adrenolytic Agent Mitotane 11 P-hydroxylase. Inhibits steroidogenesis intermittently 2-6 g/day in 3-4 Gl intolerance (high Used primarily for adrenal... 

Recent experiments carried out by BOLME and coworkers (39) now raise the question of whether the receptors involved in reducing blood pressure are epinephrine receptors or noradrenaline receptors. These workers found that in rats small doses of yohimbine and piper-oxan blocked the blood pressure lowering effect of clonidine, but did not influence the clonidine-induced increase in flexor reflex activity. This effect on the reflex mechanism is possibly mediated by noradrenaline receptors which can be blocked only by higher doses of a-adrenolytic agents. HtfKFELT et al. (40) consider that epinephrine terminals possibly innervate noradrenaline cell bodies at the locus coeruleus. 

Figure 4 is one of the illustrations from a recent publication by Euler. After the administration of an adrenolytic agent, Dibenamine, the pressor effect of adrenaline was in large measure reversed whereas the pressor response to corresponding increments of l-noradrenaline and to extracts of spleen or splenic nerve remained upright and monophasic. In general the effect of hepatic nerve stimulation is not affected by amounts of adrenolytic agents that will reverse the response to epinephrine (48, 75,163). 

Figure 4. Blood Pressure Records from Anesthetized Cat before and following Administration of Adrenolytic Agent...

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