Adrenocorticotropic hormone analogues

Terasaki T, Takakuwa S, Saheki A, Moritaui S, Shimura T, Tabata S, Tsuji A (1992) Absorptive-mediated endocytosis of an adrenocorticotropic hormone (ACTH) analogue, ebiratide, into the blood-brain barrier Studies with monolayers of primary cultured bovine brain capillary endothelial cells. PharmRes 9 529—534. 

The effect of protease inhibitors on the stability of ebiratide in the gastrointestinal tract was also examined [37]. Ebiratide (H-Met(02)-Glu-His-Phe-D-Lys-Phe-NH(CH2)8 NH2), a newly synthesized adrenocorticotropic hormone (ACTH) derivative, was developed for the treatment of Alzheimer s-like dementia, as it acts directly on the central nervous system. Ebiratide has been reported to have potent neurotrophic effects in rats and mice following peripheral administration, and has superior biological stability compared with the native ACTH4.10 fragment and the ACTH analogue (H-Met(OJ-Glu-His-Phe-D-Lys-Phe-NH2) [38-40]. 

Schimmer BP, Parker KL. Adrenocorticotropic hormones. Adrenocortical steroids and their synthetic analogues. In Brunton II, Lazo JS, Parker KL, ed. Goodman Gilman s The Pharmacological Basis of Therapeutics. 11th Ed. New York McGraw-Hill, 2006 1587-1612. 

B. P. Schimmer and K. L. Parker, Adrenocorticotropic hormone adrenocortical steroids and their synthetic analogues inhibitors of the synthesis and actions of adrenocortical hormones, in Goodman and Gilman s The Pharmacological Basis of Therapeutics, ed. J. G. Hardman, L. E. Limbird, P. B. Molinoff, R. W. Ruddon and A. G. Gilman, McGraw-Hill, London, 9th edn, 1996, pp. 1459-1485. 

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