Adrenergica

The presence of a P-C substituent limits the pathway of biotransformation of ephedrine to p-hydro-xylation, N-dealkylation, and deamination. Dealkylation and subsequent deamination is the major route of metabolism of ephedrine in most species, excluding the rat (Williams et al. 1973). 

Phenylephrine is an ai-adrenergic agonist. However, it simultaneously activated P-adrenoceptors and can therefore be used as a selective ar adrenoceptor agonist only in the presence of P-blockade (van Meel et al. 1981). Phenylephrine was reported to induce Ca efflux, but not influx, in the perfused rat Uver in the presence of 1.3 mM Ca in the medium (Altin and Bygrave 1985). Kleineke and Soling (1987), however, reported that Ca influx can occur with phenylephrine under these conditions. 

Adrenaline in very large dose (2.5 mg/kg mouse) rapidly dilated the cisternae of the smooth endoplasmic reticulum of the Clara cells with subse- 

Smooth endoplasmic reticulum in the apical part of a type 1 Clara cell from a female rat (breeder Winkelmann, Borchen-Kirchborchen) which inhaled 300 jug micronized (mass median diameter 2.45 um) phenylephrine bitartrate/ 

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Adrenergica (nonselective) AdrenergicaA AdrenergiCae Adrenergic (nonselective) AdrenergiCi... 

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