Adrenergic receptor-blocking

RNHCH.CH(OHlCH— R R P Adrenergic receptor blocking agents 473... 

RNHCH CH(OHiCH - heteroarvl H /3-Adrenergic receptor blocking agents 179... 

Hugget D, Brook B, Peterson B, Foran CM, Schlenk D (2002) Toxicity of selected beta adrenergic receptor-blocking pharmaceuticals (B-blockers) on aquatic organisms. Arch Environ Contam Toxicol 43 229-235... 

Hnggett, D.B., Brooks, B.W., and Peterson, B. et al. (2002). Toxicity of select beta adrenergic receptor blocking pharmaceuticals (beta blockers) on aqnatic organisms. Archives Environmental Contamination and Toxicology 41, 229-235. 

Huggett, D.B., Khan, I.A., Foran, C.M., and Schlenk, D., Determination of beta-adrenergic receptor blocking pharmaceuticals in United States wastewater effluent, Environ. Pollut., 121, 199-205, 2003. 

Communication with the profession was at first maintained by continuing (until January 1985) the Adverse Reaction Series leaflets started by CSD, and later by a regularly published bulletin on Current Problems . The first issue of Current Problems in September 1975 led with the adverse oculo-cutaneous effects and sclerosing peritonitis associated with p-adrenergic receptor blocking agents and also included items on loss of consciousness associated with prazosin and on the risks of anti-inflammatory agents and asthma. 

Napamezole (68) is a dihydroimidazole denvative with antidepressant activity probably as a result of its combined a 2 adrenergic receptor blocking and serotonin uptake blocking proper ties It can be synthesized by Wittig olefinabon of p-tetralone (65) with diethyl (cyanomethyl) phosphonate (66) and base to give nitnle 67 Imidazoline construction on the latter was smoothly... 

What is the primary reason for administering (3-adrenergic receptor blocking drugs as adjunct therapy in the treatment of thyrotoxicosis ... 

Suzman, M.M. Use of p-adrenergic receptor blocking agents in psychiatry. In Palmer,... 

Fexofenadine inhibited antigen-induced bronchospasm and histamine release from mast cells. No anticholinergic or alpha adrenergic-receptor blocking effects were observed. Moreover, no sedative or other CNS effects were observed. Fexofenadine does not cross the blood-brain barrier. It inhibits skin wheal and flare responses produced by histamine injection. Following single and twice daily oral administration, antihistaminic effects occurred within 1 hour, achieved a maximum at 2-3 hours, and lasted a minimum of 12 hours. 

Among the -adrenergic receptor-blocking agents used in food-producing animals for the prevention of shipment stress caused by transportation and formation of new herds, carazolol and propranolol are the best-known representatives (Fig. 8.7). 

The calcium antagonistic and ct]-adrenergic receptor blocking activities of monatepil maleate (( )-iV-(6,ll-dihy-drodibcnzo[/Af ]thiepin-l 1 -yl)-4-(4-fluorophenyl)-l -piperazinebutanaruidc monomaleate, AJ-2615 267), its metabolites (AJ-2615-sulfoxide A, AJ-2615-sulfoxide B 268, and AJ-2615-sulfone 269), and their enantiomers were studied... 

AF1057>. There was a difference in the calcium antagonistic activities between the enantiomers of monatepil maleate 267 but not in their cti-adrenergic receptor blocking activity. 

Summary Pharmacology of P-Adrenergic Receptor-Blocking Agents... 

Ojha T, Bakshi M, Chakraborti AK, Singh S. The ICH guidance in practice stress decomposition studies on three piperazinyl quinazoline adrenergic receptor-blocking agents and comparison of their degradation behavior. J Pharm Biomed Anal 2003 31 775-783. 

Testing the concept required the preparation of pure samples of each of the four enantiomers. These were prepared by Gold et al.3 and Chemical Development using classical resolution and chiral synthesis methods. It was quickly found that the RR enantiomer, later named dilevalol, was virtually free of a-adrenergic receptor blocking activity and also possessed superior vasodilator properties versus labetalol. 

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