Adrenergic blocking drugs combinations

Hydralazine is usually used in combination with other drugs. In recent years, it has been found to be especially useful when used with beta-adrenergic blocking agents and diuretics (3,4). 

Treatment of atrial fibrillation is initiated to relieve patient symptoms and prevent the complications of thromboembolism and tachycardia-induced heart failure, the result of prolonged uncontrolled heart rates. The initial treatment objective is control of the ventricular response. This is usually achieved by use of a calcium channel-blocking drug alone or in combination with a 13-adrenergic blocker. Digoxin may be of value in the presence of heart failure. A second objective is a restoration and maintenance of normal sinus rhythm. Several studies show that rate control (maintenance of ventricular rate in the range of 60-80 bpm) has a better benefit-to-risk outcome than rhythm control (conversion to normal sinus rhythm) in the long-term health of patients with atrial fibrillation. If rhythm control is deemed desirable, sinus rhythm is usually restored by DC cardioversion in the USA in... 

Nitrates may be combined with other drugs for anginal therapy, including -adrenergic blocking agents and calcium channel... 

ADVERSE EEEECTS AND PRECAUTIONS The /3 adrenergic blocking agents should be avoided in patients with asthma, with sinoatrial or atrioventricular (AV) nodal dysfunction, or in combination with other drugs that inhibit AV conduction, such as verapamil. Patients with type 1 diabetes mellitus also are better treated with other drugs e.g., ACE inhibitors). 

Edoute Y, Nagachandrati P, Svirski B, Ben-Ami H. Cardiovascular adverse drug reaction associated with combined p-adrenergic and calcium entry-blocking agents. J Car ovasc Pharmacol 2000) 35, 556-9. 

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