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ADMET-pharmacokinetics studies

Absorption, distribution, metabolism, excretion, and toxicology (ADMET) properties determine the pharmacokinetic and safety behavior of compounds and thus to a large part, how effective a compound acts as a drug, how the compound has to be dosed, and what safety window has to be considered. Due to the decisive role of ADMET properties in lead optimization and drug development, these parameters are investigated very early by in vitro systems. For example, Caco-2 cell lines are used to estimate permeability of compounds, while liver microsomes are used to study metabolic stability of novel compounds in vitro [1,2]. [Pg.245]

See other pages where ADMET-pharmacokinetics studies is mentioned: [Pg.762]    [Pg.64]    [Pg.23]    [Pg.91]    [Pg.256]    [Pg.211]    [Pg.266]    [Pg.469]    [Pg.501]    [Pg.202]    [Pg.784]    [Pg.248]    [Pg.329]    [Pg.396]    [Pg.216]   
See also in sourсe #XX -- [ Pg.450 ]



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