ADME-PK Screening Rationale

Conceptually, the strategy for ADME-PK screening in drug discovery can be compared to decathlon event as stated by Kerns and Di [21]. A specific ADME-PK screen is analogous to a specific athletic event. The overall winner is not necessarily the lead compound that exhibits the best performance in any single ADME-PK screen, but simply has adequate characteristics in all ADME-PK screens. 

So it can be generalized that a standard series of ADME-PK screening assays is assembled during the initiation of a drug discovery program. A drug candidate must 

Using Mass Spectrometry for Drug Metabolism Studies 

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