Adjuvants Toll-like receptors

Tamayo I, Irache JM, Mansilla C et al (2010) Poly(anhydride) nanoparticles act as active Thl adjuvants through Toll-like receptor exploitation. Clin Vaccine Immunol 17 1356-1362... 

Kaisho,T. and Akira, S., Toll-like receptors as adjuvant receptors, Biochim. Biophys. Acta., 1589, 1, 2002. 

Synthesis of Toll-Like Receptor-2 Targeting Lipopeptides as Self-Adjuvanting Vaccines... 

Interactions between lipids and receptors for structurally conserved pathogen-associated molecular patterns, most commonly the Toll-like receptors (TLRs), have been studied in detail for their involvement in adjuvant activity. TLRs appear to play an important role in the functioning of many adjuvants and the most important TLRs for lipopeptide or glycolipopeptide vaccines are TLR1, TLR2, TLR4, and TLR6 (van Duin et al. 2006). 

Brayden DJ, Baird AW (2001) Microparticle vaccine approaches to stimulate mucosal immunisation. Microb Infect 3(10) 867-876 Brewer JM (2006) (How) do aluminium adjuvants work Immunol Lett 102(1) 10-15 Buwitt-Beckmann U, Heine H, Wiesmuller KH, Jung G, Brock R, Akira S, Ulmer AJ (2005) Toll-like receptor 6-independent signaling by diacylated lipopeptides. Eur J Immunol 35(1) 282-289... 

Ishizaka, S.T., Hawkins, L.D. E6020 a synthetic Toll-like receptor 4 agonist as a vaccine adjuvant. Exp Rev Vaccines 6 (2007) 773-784. 

Kaisho, T. and S. Akira (2002). "Toll-like receptors as adjuvant receptors." Biochimica. Biophysica Acta 1589 1-13. 

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