Adipose tissue glucose transporter function

The uptake of glucose by brain, liver, kidneys, erythrocytes, and the islets of Langerhans is unaffected by insulin. However, in muscle and adipose tissues insulin stimulates glucose uptake. Part of this effect results from insulin-induced translocation of molecules of the 509-residue glucose transport protein GLUT4 (Chapter 8) from the cytosol into the plasma membrane where it can function.354-3563 Insulin apparently also increases the rate of synthesis of the transporters. 

One of the functions of insulin is to stimulate the movement of glucose into cells. Only a limited number of tissues are sensitive to insulin, however, including the heart, skeletal muscle, and adipose tissue. Liver, kidneys, and brain are not sensitive to insulin, although they contain glucose transporters. Glucose transporters of insulin-sensitive tissues are normally stored in the microsomes... 

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