5 -Adenosyl-L-methionine decarboxylase

The aromatic diamidines are compounds of considerable pharmaceutical interest. This is, among others, for the following reasons they have a strong antiprotozoan action and participate in the metabolism and transport of polyamines, inhibiting, for instance, 5-adenosyl-L-methionine decarboxylase (SAMDC). Therefore, because this route is closely linked to cell proliferation processes, aromatic diamidines can slow down or prevent the growth of tumors. The substances used in this work are as follows " ... 

Fig. 8.5 Compartmentation of alkaloid biosynthesis in Cathamnthus roseus. AS anthianilate synthase, CR NADPH cathenamine reductase, DAT deacetylvindoline 17-O-acetyltransferase, ER endoplasmic reticulum, GlOH geraniol 10-hydroxylase, GAP glyceraldehyde-3-phosphate, NMT S-adenosyl-L-methionine methoxy-2, 16-dihydro-16-hydioxylagersonine-lV-methyltransferase, OHT desacetoxyvindoline-4-hydroxylase, SGD strictosidine -glucosidase, STR strictosidine synthase TDC tryptophan decarboxylase, THAS NADPH tetrahydroalstonine reductase (Adopted from Ref. [10])... 

---