Adenosine triphosphate concepts

The first two compounds have particularly important bio functions in connection with energy storage. Creatine phosphate was first isolated by Eggleton [13] from frog muscle in 1927. The concept of high-energy phosphate bonds was introduced in 1941 by Lipmann [8], who postulated that adenosine triphosphate (ATP) (11.10a) functioned in a cyclic manner as the energy carrier in the numerous... 

The proof of concept example examined the cardiac glycoside digitoxin (Scheme 3.15, 61). Digitoxin is an interesting target as it is a well-known inhibitor of the plasma membrane Na+/K" -ATPase (ATP, adenosine triphosphate), hut also is known to have anticancer activity, activity against polyglutamine disorders, and to... 

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