Adenosine-3 -phosphate-5 -phosphosulphate PAPS

Sulphate conjugates, once called ethereal sulphates because of their extraction characteristics, are of two major types aryl or alkyl sulphates (which are esters of phenols or alcohols) and steroid sulphates. The sulphate moiety is transferred from the cofactor adenosine-3 -phosphate-S -phosphosulphate (PAPS) to an acceptor by enzymes known as sulphotransferases or sulphokinases. The enzymes which catalyse the formation of PAPS as well as the sulphokinases are in the soluble fraction of liver ... 

P = high energy phosphate bond PAL = phenylalanine ammonia lyase PAPS = 3 -adenosine-5 -phosphosulphate Pi = inorganic orthophosphate PPi = inorganic pyrophosphate PEP = phosphoenolpyruvate... 

Figure 1 Phase I and Phase II metabolic pathways. PAPS, adenosine 3 -phosphate S -phosphosulphate UDPGA, uridine diphosphate glucuronic acid.

PAP = adenosine 3, 5 -diphosphate PAPS = adenosine 3 -phosphate 5 -phosphosulphate)... 

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