Adenine silver salt

Direct condensation of 2,3,5-tri-0-benzoyI-/3-D-ribofuranosyl bromide with adenine in acetonitrile at 50 °C leads after deblocking to the 3-/3-D-ribofuranosyladenine (132) (B-68MI40901). Metal derivatives of purines tend to produce 7- or 9-glycosyl derivatives thus the silver salt of 2,8-dichloroadenine with 2,3,5-tri-O-acetylribofuranosyl chloride produces the 9-/3-D-ribofuranosyl derivative (133) (48JCS967, 48JCS1685). However similar reactions with theobromine produce O-glycosides and with theophylline N-7 derivatives (34JCS1639). 

The silver salt of 3-carbamoyl-6-pyridone and l-chloro-2,3,5-tri-0-benzoyl-P-D-ribofliranose give 3-carbamoyl-iV-

with sodium methoxide. This nucleoside has been converted to 3-carbamoyl-6-pyridone adenine dinucleotide. ... 

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