Adenine lactate dehydrogenase coenzyme bind

The enzyme lactate dehydrogenase, which catalyzes the transfer of electrons from lactate to NAD, illustrates these principles (Fig. 8.14). The coenzyme nicotinamide adenine dinucleotide (NAD ) is synthesized from the vitamin niacin (which forms the nicotinamide ring), and from ATP (which contributes an AMP). The ADP portion of the molecule binds tightly to the enzyme and causes conformational... 

Like metal ions, the small organic molecules that act as coenzymes bind reversibly to an enzyme and are essential for its activity. An interesting feature of coenzymes is that many of them are formed in the body from vitamins (see > Table 10.2), which explains why it is necessary to have certain vitamins in the diet for good health. For example, the coenzyme nicotinamide adenine dinucleotide (NAD ), which is a necessary part of some enzyme-catalyzed oxidation-reduction reactions, is formed from the vitamin precursor nicotinamide. Reaction 10.5 shows the participation of NAD in the oxidation of lactate by the enzyme lactate dehydrogenase (LDH). Like other cofactors, NAD is written... 

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