Addressing Vast Chemical Space HtL Strategies

If one begins to venture outside of drug-like space (e.g., PPIs), then the numbers would be expected to be significantly higher than 10 °. One can then begin to understand why an SAR by your favorite chemical vendor approach to 

Available drug-like space Typical screening collection 

If a typical screening collection filled a postcard, a conservative estimate of the available drug-llke space Is the entire earth. 

4 Addressing Vast Chemical Space HtL Strategies 1347 Key Side Chain SAR emerging 

Identification of 6 lead series (Example molecule from one of the series) 

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