1-adamantyl 4-methoxyphenyl

The solvolysis mechanisms of 2,2-dimethyl-3-pentyl- and l-(l-adamantyl)-propyl sulfonates appeal- to involve partial reversible ionization to the ultimate ion pair followed by competing elimination and solvent separation, substitution products being formed from the separated ions.27 The lifetimes of simple tertiary carbocations may be some 100 times shorter than previously thought several 3-(4-methoxyphenyl)-l,l-dimethylpropyl species hydrolyse in 50% aqueous TFE with rate constants estimated at some 3.5 x 1012 s-1.28 Much elimination was also observed.28 Two studies concerning proposed carbocation intermediates in enzymatic processes are reported.29,30... 

Competition experiments have been carried out to determine the relative reactivities of 23 alkyl chlorides toward allyltrimethylsilane in the presence of ZnCh. The kre scale has been found to span 11 orders of magnitude from the least reactive 1-adamantyl chloride to the most reactive bis(p-methoxyphenyl)methyl chloride384. By contrast, analogous acetals RCH(OMe)2 exhibited very little differences in reactivity385. 

Preparation of 6-(3-(l-adamantyl)-4-methoxyphenyl)-2-naphthoic acid consist of 4 steps. 

The invention [87] relates to the discovery that specific adamantyl or adamantyl group derivatives containing retinoid-related compounds induce apoptosis of cancer cells and therefore may be used for the treatment of cancer, including advanced cancer. It has been shown that such adamantyl compounds, e.g., 2-[3-(l-adamantyl)-4-methoxyphenyl]-5-benzimidazole carboxylic acid 135), can be used to treat or prevent cervical cancers. 

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