Acylisothiocyanates acids

Lieber et al. have discussed whether the compound obtained from the sodium salt of the thiol and methyl iodide is an A- or an /S-deriv-ative and have proved that it is the /S-derivative by syntheses of this compound from methyl dithiocarbazinate (CHgS—CS—NH—NH2) and nitrous acid. The acyl derivatives are, however, formulated as A-acylthiatriazoline-6-thiones, because they are decomposed to form acylisothiocyanates. Lieber et have shown that thiocyanates... 

The poor reaction with C-terminal proline most likely stems from the fact that proline cannot form the necessary oxazolinone for efficient reaction with the isothiocyanate. Work in our laboratory has obviated the need for oxazolinone formation by the use of diphenyl phosphoroisothiocyanatidate and pyridine. Reaction of this reagent with C-terminal proline directly forms the acylisothiocyanate. Once the acylisothiocyanate is formed, the addition of either liquid or gas phase acid followed by water was... 

Once an acylisothiocyanate is formed it can cyciize to a quaternary amine containing thiohydantoin. This thiohydantoin, if protonated with acid, is stabie. If the acid step is eiiminated C-terminal proiine is regenerated. The quaternary amine containing proiine thiohydantoin can be readiiy cleaved with water vapor or aiternativeiy with the siianoiate salt normally used for the cleavage reaction. 

Acylamino-l-thioethers N-Acylcarboxylic acid thioamides Acylisothiocyanates Cyanothioformic acid esters Methylthiomethyl iminoesters l-(Organothio)alkoximes... 

Acylamino-1 -thioethers N-Acylcarboxylic acid thioamides Acylisothiocyanates Acylthiocyanates N-Acylthioiminoesters N-a-Alkoxycarboxylic acid thioamides... 

Bromine via y -amino-a,) -ethylenecarboxylic acid tbioamides from acylisothiocyanates s. 18, 354 Br... 

Amino-a,y -ethylenecapboxylic acid thioamides from acylisothiocyanates... 

Acylisothiocyanates from carboxylic acid chlorides GOCl GON G S... 

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