Acylation of Enolates and Other Carbon Nucleophiles

Acylation of carbon nucleophiles can also be carried out with more reactive acylating agents such as acid anhydrides and acyl chlorides. These reactions must [Pg.150]

Ushitogochi, S. Sano, and Y. Nagao, Chem. Lett., 295 (1995). [Pg.150]

Reactions of Carbon Nucleophiles with Carbonyl Compounds [Pg.152]

Monoalkyl esters of malonic acid react with Grignard reagents to give a chelated enolate of the malonate monoanion. [Pg.152]

These carbon nucleophiles react with acyl chlorides220 or acyl imidazolides.221 The initial products decarboxylate readily so the isolated products are (3-ketoesters. [Pg.152]

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