Acyl pocket binding site

Sequence Peripheral site Choline binding site Acyl pocket ... 

Comparison of the KS binding sites from homology models tallies well with the experimental data for these KS domains. In order to test the hypothesis that a bulky residue at the X-Cys position precludes acylation by fl-carbon branched substrates, a M237A mutant was proposed. Simple alteration to the homology model suggested that a Met to Ala mutation would indeed provide additional space in the binding pocket for a f)-branched substrate (Fig. 3.9). 

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