Activation of Calpains and Other Proteases in Spinal Cord Injury

9 Activation of Calpains and Other Proteases in Spinal Cord Injury 

Calpains are a family of calcium-dependent cysteine proteases that are widely expressed in brain and spinal cord tissues. These enzymes have been implicated in cell death in spinal cord injury (Ray et al., 2003 Buki et al., 2003). Calpain activity is modulated by an endogenous protein inhibitor called calpastatin. Overactivation 

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