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Activated carcinogen-nucleotide bases

Metabolically activated carcinogens covalently bind in vitro to mouse epidermal DNA similar to in vivo (Nakayama et al. 1984). In vitro DNA repair processes operate to fix single-strand DNA. There is base excision, nucleotide excision, mismatch repair as well as double-strand repair (for double-strand breaks), and UV and... [Pg.106]

In this section we should like to point out the possibility of two different kinds of solitons (non-linear quasi particles) in a nucleotide base stack. They quite probably play an important role in long-range effects of chemical carcinogens and direct hits of ionizing radiations along a DNA double helix. In this way they may play an important role in the activation of oncogenes or in the inactivation of antioncogenes. [Pg.496]

See other pages where Activated carcinogen-nucleotide bases is mentioned: [Pg.400]    [Pg.1548]    [Pg.496]    [Pg.328]    [Pg.119]    [Pg.243]    [Pg.630]    [Pg.1148]    [Pg.309]    [Pg.145]    [Pg.816]    [Pg.315]    [Pg.230]    [Pg.232]    [Pg.420]    [Pg.41]    [Pg.198]    [Pg.492]   
See also in sourсe #XX -- [ Pg.72 , Pg.171 ]



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