Actinomycins catabolite repression

The relationship between catabolite repression by glucose and induction of cellulase by sophorose has been studied in T. viride by Nisizawa and co-workers (36, 37). The induction by sophorose (10 M) was competitively repressed by glucose and other metabolites such as pyruvate. Since glucose was an effective repressor when added one hour after the previous addition of actinomycin D, it was concluded that the repression takes place at the translational level. Previous work indicated (26) that the sophorose induction led to the formation of a cellulase component designated FII, which is the source of cellulase II discussed below. In higher plants indoleacetic acid (38) and abscisic acid (39) have been shown to stimulate cellulase production. 

Gallo M, Katz E. Regulation of secondary metabolite biosynthesis Catabolite repression of fihenoxazitKine and actinomycin fewnution by glucose. J Bacteriol 1971 109 659-667. 

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