Actinomycin crystal structure

The blue oxidases-related enzymes include phenoxazinone synthase from S. antibioticus This enzyme is a copper-containing oxidase that catalyzes the coupling of 2-aminophenols to form the 2-aminophenoxazinone chromophore. This reaction constitutes the final step in the biosynthesis of the potent antineoplastic agent actinomycin. The crystal structure of the oxidized form phenoxazinone synthase from S. anibioticus has been determined. It has been solved in his hexameric form. One monomer is very similar to Iaccase or ascorbate oxidase but it contains a long loop, which connects two domains and stabilizes the hexameric structure. Bound... 

Actinomycin-D. easily available and very active, is the best-known member of this family of peptidic antibiotics. The two peptide chains are supported by a three-conjugated ring structure acting as chromophore. These substances have a bright colour red crystals, yellow-orange solutions. 

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